Safety and side effect profile of Pfizer-BioNTech COVID-19 vaccination among healthcare workers: A tertiary hospital experience in Singapore

ABSTRACT Introduction: Vaccination remains a key strategy to living endemically with COVID-19. The Pfizer-BioNTech COVID-19 vaccine was first granted interim authorisation for use in Singapore December 2020. With overseas studies published about the safety and side effect profiles of mRNA vaccines focusing mainly on non-Asian populations, we described effects vaccination experienced by healthcare workers (HCWs) tertiary hospital Singapore. Methods: Data were obtained from Occupational Health Clinic (OHC) at National University Hospital Singapore, which monitored staff any adverse within 30 minutes postvaccination on-site after that. A cross-sectional study among vaccinated HCWs conducted using an online survey, established basic demographics, histories allergies or atopic disorders, events encountered dose 1 2 vaccination. Results: No anaphylaxis reported. Most common symptom giddiness (32.7%) minutes. Adverse attended post-vaccination OHC generally mild self-limiting. From odds experiencing event significantly higher than dose, especially fever/chills (odds ratio [OR] 22.5). Fever/chills, injection site reactions, headache, aches pains, feeling unwell more below 60 years compared those ≥60 years. An allergy food (adjusted OR 2.7) history eczema/sensitive skin 2.6) associated reaction not site. Conclusion: are self-limiting mild, no Keywords: COVID-19, infectious diseases, occupational medicine, effects,